Visual read performance of 18F-Florbetapir and 18F-NAV4694 Aβ PET compared against Centiloid reference standard in a paired cohort

Abstract

INTRODUCTION: Visual assessment remains standard practice to rule out amyloid-β (Aβ) pathology. 18F-NAV4694 (NAV) has high affinity for Aβ potentially detecting lower levels than other F-18 Aβ tracers. METHODS: One hundred fifty participants in the AIBL study underwent both 18F-Florbetapir (FBP) and NAV Aβ PET scans. PET scans were assessed by six nuclear medicine physicians against Centiloid (CL) quantification. An optimized reference region was utilized for FBP as it improved CL–visual read correlations. Inter-reader agreement of visual assessment was measured using Fleiss’ Kappa. RESULTS: Mean peak accuracy for visual read exceeded 95% for both NAV and FBP. However, peak accuracy for NAV ..